Marseille, Sept 15-16th, 2025

Biohybrid systems where enzymes are integrated with artificial materials, have been extensively explored to deepen our understanding of enzymatic function and to enhance their compatibility for practical applications. These systems incorporate a wide range of enzymes, including natural, artificial, engineered, chimeric, and de novo enzymes, and are coupled with diverse artificial materials such as electrodes, photosensitizers, synthetic catalytic systems, hydrogels, liposomes, and nanoparticles. Applications span across sensing, energy conversion, and electrosynthesis.

As the field matures, research has increasingly focused on elucidating the biotic-abiotic interface, with a particular emphasis on energy and electron transfer mechanisms. This workshop will focus on the latest advancements in electrochemical, spectroscopic, and modeling tools that provide mechanistic insights into these interactions. Additionally, we will explore novel strategies for designing and constructing biohybrid systems.

Key Topics:

• Enzymes specifically engineered for biohybrid applications.
• Strategies for wiring multi-enzyme systems to enable efficient electron transfer.
• Replacement of natural cofactors (NAD(P)H, ATP) with artificial systems.
• Understanding confinement effects on multienzyme reactions in controlled environments.
• Development of chimeric systems to investigate reaction mechanisms or combine desirable enzymatic features.
• Biohybrid light-driven systems for harvesting energy and extracting electrons.
• Encapsulation and protective matrices to enhance the robustness of fragile enzymes.

This workshop will provide a platform for discussing cutting-edge approaches in biohybrid catalysis, fostering collaborations, and shaping the future of enzyme-based technologies.

Program

Monday

9am, welcome, coffee

9:15 conference starts

Session chaired by Marine Desage-El Mur, Strasbourg University

9:25 Inês Pereira, ITQB, New Univ. of Lisbon, P., “The W/Sec-formate dehydrogenase from Nitratidesulfovibrio vulgaris as a model system for enzymatic biohybrid CO2 conversion”

10:00 Leigh Aldous, National Taiwan University, “Exploring novel viologens as electron transfer mediators for reductase enzymes”

10:35: coffee break

11:05 Clare Megarity, Manchester Univ., UK “An Engineered Ferredoxin-NADP+ Reductase: from Electrochemical Insight to the Interactive Control of Enzyme Cascades”

11:40 Yutaka Amao, Osaka Metropolitan University, Japan, “Photoelectrochemical carbon dioxide conversion using FeOOH/BiVO4/CuInS2 tandem system with multi-biocatalyst”

12:15 lunch

Session chaired by Wadih Ghattas, CNRS, Saclay, France

14:00 Jenny Zhang, Cambridge University, UK, “Photosynthesis on an electrode”

14:35 Bertrand Reuillard, UGA, CEA, Grenoble, “Molecular engineering of cobalt based cathodes for CO2 reduction”

15:10 Scott Calabrese Barton, Michigan State Univ., USA, “Multiscale Modeling of Bioelectrocatalytic Cascades”

15:45 Coffee break

16:15 Moritz Kühnel, University of Hohenheim, Germany, “Enzyme-nanoparticle hybrids for photocatalytic H2 generation in the presence of O2”

16:50 Thierry Tron, CNRS, AMU, Marseille, F, “Bio-hybrid systems based on multi-copper oxidases”

17:25 : Leonardo Castaneda, Cambridge, UK, “CO2-Fixation Through Bioelectrocatalytic Cofactor Regeneration”

Tuesday

9am: welcome, coffee

Session chaired by Elisabeth Lojou, CNRS, Marseille, France

9:25 Tara Lurshay, from Hydregen, UK, “Biocatalytic hydrogenation: robust biotechnologies for sustainable chemical manufacturing”

10:00 Alan Le Goff, UGA, CNRS, Grenoble, F, “CO dehydrogenases on carbon nanotubes for Water-Gas-Shift Reaction and CO2-to-CO conversion”

10:35 coffee

11:05 Ievgen Mazurenko, Marseille, F. “Uncovering the role of Met-rich domains in CueOs’ activity and electrocatalysis”

11:40 Jinrong Zhang, CNRS, Marseille, F, “Analytical Treatment of the Reversible-Enzyme-Redox-Film-Electrode Systems”

12:15 lunch

Social Event

Trip to the Frioul island on Tuesday afternoon, hike and swim.

Scientific committee

• Christophe Léger (BIP, CNRS, AMU)
• Jalila Simaan (IsM2, CNRS, AMU)
• Vincent Fourmond (BIP, CNRS, AMU)
• Nicolas Plumeré (TUM)

Picture Gallery

Register before Sept 5th

The 30€ registration fees include access to conference rooms, coffee breaks and lunches on the 15th and the 16th of September.

Speakers: do not register.

Attendees: please register -> here <- via the HelloAsso platform.

NB: HelloAsso will suggest that you pay a tip to support the platform ; you can reset this to zero if you do not want to.

Registration is free for speakers and members of IM2B. Use the promo code “IM2B” if your registration is covered by us.

Venue

Amphitheatre Touze, Palais du Pharo, near Marseille old harbor.